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Gua Operon
The gua operon is responsible for regulating the synthesis of guanosine mono phosphate(GMP), a purine nucleotide, from inosine monophosphate (IMP or inosinate). It consists of two structural genes guaB(encodes for IMP dehydrogenase or IMPDH) and guaA(encodes for GMP synthetase) apart from the promoter and operator region. == Purine Biosynthesis == The first committed step of purine biosynthesis starts from 5-phosphoribosyl 1 pyrophosphate (PRPP). This undergoes a series of reactions to form IMP, an important branch point in the pathway. The pathway then branches to form adenylosuccinate and then adenylate(AMP) in one branch and xanthylate (XMP) and then guanylate (GMP) in the other branch. IMP dehydrogenase catalyses the conversion of IMP to XMP and GMP synthetase catalyses the conversion of XMP to GMP.
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Gua Operon」の詳細全文を読む
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